{"id":110354,"date":"2026-10-26T05:20:56","date_gmt":"2026-10-26T05:20:56","guid":{"rendered":"https:\/\/gpcregulatory.com\/?page_id=110354"},"modified":"2026-10-26T06:22:53","modified_gmt":"2026-10-26T06:22:53","slug":"research-development-program-at-gpc","status":"publish","type":"page","link":"https:\/\/gpcregulatory.com\/fr\/research-development-program-at-gpc\/","title":{"rendered":"Research &#038; Development"},"content":{"rendered":"<div data-elementor-type=\"wp-page\" data-elementor-id=\"110354\" class=\"elementor elementor-110354\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b37ff0 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"1b37ff0\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3412eb9\" data-id=\"3412eb9\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f420590 elementor-widget elementor-widget-spacer\" data-id=\"f420590\" data-element_type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 08-05-2024 *\/\n.elementor-column .elementor-spacer-inner{height:var(--spacer-size)}.e-con{--container-widget-width:100%}.e-con-inner>.elementor-widget-spacer,.e-con>.elementor-widget-spacer{width:var(--container-widget-width,var(--spacer-size));--align-self:var(--container-widget-align-self,initial);--flex-shrink:0}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container,.e-con>.elementor-widget-spacer>.elementor-widget-container{height:100%;width:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer{height:100%}.e-con-inner>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner,.e-con>.elementor-widget-spacer>.elementor-widget-container>.elementor-spacer>.elementor-spacer-inner{height:var(--container-widget-height,var(--spacer-size))}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty,.e-con>.elementor-widget-spacer.elementor-widget-empty{position:relative;min-height:22px;min-width:22px}.e-con-inner>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon,.e-con>.elementor-widget-spacer.elementor-widget-empty .elementor-widget-empty-icon{position:absolute;top:0;bottom:0;left:0;right:0;margin:auto;padding:0;width:22px;height:22px}<\/style>\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ba1edf6 elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"ba1edf6\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d3d67a8\" data-id=\"d3d67a8\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1126ed8 elementor-widget elementor-widget-heading\" data-id=\"1126ed8\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 08-05-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">GPC Research &amp; Development Programme 2026<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b44bd3c elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"b44bd3c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1a9c21a\" data-id=\"1a9c21a\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f6a9958 elementor-widget elementor-widget-heading\" data-id=\"f6a9958\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Objectives, research streams, collaborations and results, 2019\u20132028 <\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3ea01cd elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"3ea01cd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7a452b3\" data-id=\"7a452b3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-532b2ea elementor-widget elementor-widget-text-editor\" data-id=\"532b2ea\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 08-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p><strong><span class=\"TextRun SCXW45057209 BCX0\" lang=\"EN-US\" xml:lang=\"EN-US\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW45057209 BCX0\" data-ccp-parastyle=\"Date\">Global Product Compliance (Europe) AB \u2013 internal document, October 2026<\/span><\/span><\/strong><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0e8e7dd elementor-section-boxed elementor-section-height-default elementor-section-height-default wpr-particle-no wpr-jarallax-no wpr-parallax-no wpr-sticky-section-no\" data-id=\"0e8e7dd\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a88d050\" data-id=\"a88d050\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c77cf98 elementor-widget elementor-widget-text-editor\" data-id=\"c77cf98\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<h2 aria-level=\"1\"><b><span data-contrast=\"none\">1. Purpose and overall aim<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><p><span data-contrast=\"auto\">GPC\u2019s research and development programme exists to make chemical regulation and compliance <\/span><b><span data-contrast=\"auto\">more scientific, more efficient and less dependent on new testing, especially animal testing<\/span><\/b><span data-contrast=\"auto\">. It turns GPC\u2019s practical experience as a regulatory partner and Lead Registrant into research questions, answers them with academic and industry partners, and builds the results into tools and services.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">The programme is organised around <\/span><b><span data-contrast=\"auto\">five research objectives<\/span><\/b><span data-contrast=\"auto\">:<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"6\" aria-colcount=\"3\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>No.<\/strong><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"256\"><p><strong>Objective\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Expected outcome\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">1<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><b><span data-contrast=\"auto\">Regulatory science for compliance excellence and efficiency<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Systematic knowledge of how regulations are built and depend on each other, turned into real-time, portfolio-specific compliance guidance (Intrims, RegAlert)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><b><span data-contrast=\"auto\">Avoidance of unnecessary testing<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Criteria (DIM), read-across, QSAR and machine-learning models (Jadavpur University), and a methodology that show when new studies, especially animal studies, can be scientifically avoided<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">3<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><b><span data-contrast=\"auto\">Group-based chemical safety assessment<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Approaches for assessing groups of chemicals, with a reference set of about 150 chemical safety profiles as case examples<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">4<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><b><span data-contrast=\"auto\">Data exchange and data mining<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Platforms that find existing data, interpret it against regulatory requirements and make it available for reuse (Datagap, Chemsortia)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"6\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">5<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><b><span data-contrast=\"auto\">Cost-efficient and realistic biodegradation testing<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Methods that cut the cost and time of degradation kinetics experiments by at least 50\u201360% and simulate real, complex effluents<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><span data-contrast=\"auto\">The objectives build on each other: regulatory science (1) defines what data are needed; testing avoidance (2) and group assessment (3) show how needs can be met without new studies; the data platforms (4) find and share the data that already exist; and better biodegradation methods (5) make the studies that are still needed cheaper and more relevant.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">2. GPC R&amp;D at a glance<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"9\" aria-colcount=\"2\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Item<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Summary\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Base<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Ideon Science Park, Lund (Beta 5, Scheelev\u00e4gen 17)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Core R&amp;D team<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\"><a href=\"https:\/\/www.linkedin.com\/in\/shisher\/\" target=\"_blank\" rel=\"noopener\">Shisher Kumra<\/a>, <a href=\"https:\/\/www.linkedin.com\/in\/abergq\/\" target=\"_blank\" rel=\"noopener\">Dr Anders Bergqvist<\/a>, Dr Zsuzsanna Szepesi,\u00a0<a href=\"https:\/\/www.linkedin.com\/in\/vaibhavdiwan\/\" target=\"_blank\" rel=\"noopener\">Dr Vaibhav Diwan<\/a>, <a href=\"https:\/\/www.linkedin.com\/in\/mmpelister\/\" target=\"_blank\" rel=\"nofollow noopener\">Mirach Pelster<\/a><\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Main partners<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\"><a href=\"https:\/\/www.dtu.dk\/english\" target=\"_blank\" rel=\"nofollow noopener\">DTU (Denmark)<\/a>, <a href=\"https:\/\/www.iitb.ac.in\/\" target=\"_blank\" rel=\"nofollow noopener\">IIT Bombay<\/a>, Lund University (incl.\u202fLTH), <a href=\"https:\/\/jadavpuruniversity.in\/\" target=\"_blank\" rel=\"nofollow noopener\">Jadavpur University<\/a>, the Animal-Free Safety Assessment (AFSA) Collaboration, KTH, RISE, S&amp;P Global<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Funding<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">GPC\u2019s own resources; co-financing of university projects (DTU); Vinnova-funded project with GPC in kind<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"6\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Publications<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Including four papers with Jadavpur University on read-across, QSAR and machine-learning models; peer-reviewed papers in Regulatory Toxicology and Pharmacology, Chemical Research in Toxicology, SAR and QSAR in Environmental Research and Aquatic Toxicology; further manuscripts and a book chapter in progress<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"7\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Intellectual property<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Indian patent application 202521067103 (Intrims technology), filed July 2025, published September 2026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"8\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Products from research<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Intrims (launch 2027), RegAlert, Datagap (launch December 2026), Chemsortia (launch May 2027)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"9\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Training<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">More than 20 interns and thesis students since 2019, mainly from Lund University<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><h2 aria-level=\"1\"><b><span data-contrast=\"none\">3. People and roles<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"6\" aria-colcount=\"3\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Personne\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Role\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Objectives<\/strong><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Shisher Kumra<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Leads the R&amp;D programme and the regulatory science research; concept and inventor of Intrims; concept for Datagap and Chemsortia<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">1, 4 (and PFAS within 1)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Dr Anders Bergqvist<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Head of toxicology (PhD Immunology, Lund University); leads the chemical safety profiles and the Handbook<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2, 3<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Dr Zsuzsanna Szepesi<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Researcher, in silico toxicology (PhD Immunology, Lund University); read-across, QSAR and machine-learning models with Jadavpur University; chemical safety profiles<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2, 3<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Dr Vaibhav Diwan<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Internship and DTU Research Manager (PhD, DTU 2019); also Business Development &amp; Growth<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">1, 4, 5<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"6\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Mirach Pelster<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Researcher and developer (chemical engineer, MSc)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">1, 4<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><span data-contrast=\"auto\">Regulatory dossiers and other client deliverables are prepared by GPC\u2019s regulatory staff, so that R&amp;D time and client work can be kept apart.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">4. Objective 1 \u2013 Regulatory science for compliance excellence and efficiency<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><p><b><span data-contrast=\"auto\">Why it matters.<\/span><\/b><span data-contrast=\"auto\"> Chemicals regulations worldwide differ in structure, definitions and requirements, and companies struggle to know what they must do, in which order, for each substance and market. Systematic analysis of regulations makes compliance faster, cheaper and more reliable, and helps countries design better regulation.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Research questions.<\/span><\/b><span data-contrast=\"auto\"> How are chemicals regulations structured, and how do their requirements depend on each other? Can best practice be identified and adapted to different countries? Can a country\u2019s chemicals inventory be predicted from its industrial structure? How can this knowledge be turned into real-time, company-specific guidance?<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Activities and results<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"7\" aria-colcount=\"3\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Activity\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Period\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Key result\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Chemicals inventory estimation model<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2022 \u2013 ongoing<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Predicts a country\u2019s inventory from its industry structure (manufacturing-, application- or consumer-intensive) and economic level; tested on three countries with 75\u201380% correct results; online tool in the Global Inventory Report (January 2025)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Global regulatory framework and best practice<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2022 \u2013 2026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Regulations evaluated against about 18 criteria; best practice per criterion; overall model adaptable to countries; Global Chemical Regulatory Framework (November 2026)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Survey on the impact of chemical safety regulation<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2025<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">170 industry respondents; most see a lack of regulation as harmful to business and to a level playing field (Asia Chemicals Forum 2025)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Analysis of regulatory selection of substances for evaluation<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2024 \u2013 July 2025<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">How selection for evaluation compares with substances of priority concern<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"6\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">PFAS identification and regulatory implications<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2025 \u2013 March 2027<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Computational method to identify PFAS and their sub-groups and link them to legal implications; thesis, white paper with S&amp;P Global, IPI article<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"7\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Regulatory barriers to continuous manufacturing of biologics (Vinnova, Lund University)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2024 \u2013 2025<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">GPC as regulatory partner; manuscript submitted (2026); EUFEPS presentation<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><b><span data-contrast=\"auto\">From research to products<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\u2022\" data-font=\"\" data-listid=\"2\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u2022&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"0\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Intrims<\/span><\/b><span data-contrast=\"auto\"> (2024 \u2013 launch 2027): standardises the requirements of all applicable regulations into one set of compliance actions, groups them into about 20 bundles by interdependency (OR, AND, MIXED, SINGLE logics), sequences the bundles and applies them to a company\u2019s own portfolio, with automatic re-evaluation. Tested with more than 40 users (2024) and more than 25 users (2025); upgraded after testing. Patent application 202521067103 (India).<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\u2022\" data-font=\"\" data-listid=\"2\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u2022&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">RegAlert:<\/span><\/b><span data-contrast=\"auto\"> real-time regulatory alerts based on the same knowledge base.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ul><p><b><span data-contrast=\"auto\">Data foundation.<\/span><\/b><span data-contrast=\"auto\"> Annual GPC reviews of chemicals regulations: Global Regulatory Guide, GHS Compliance guide, Global Inventory Report, Annual Summary, Compendium of Global Chemical Regulation, and the PFAS regulation overview.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">5. Objective 2 \u2013 Avoidance of unnecessary testing<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><p><b><span data-contrast=\"auto\">Why it matters.<\/span><\/b><span data-contrast=\"auto\"> Many studies requested under REACH, including animal studies, are difficult, impossible or meaningless for certain substances, or could be replaced by existing data and non-animal methods.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Research questions.<\/span><\/b><span data-contrast=\"auto\"> When is an animal test difficult, impossible or meaningless? Which read-across, QSAR and machine-learning models can reliably replace specific studies? How can a Lead Registrant decide, case by case, whether a requested study can be scientifically avoided?<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Activities and results<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"5\" aria-colcount=\"4\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Activity\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Partner<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Period<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Key result\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DIM criteria for difficult, impossible and meaningless animal testing<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">AFSA Collaboration<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Feb 2025 \u2013 Aug 2026; next phase to Q3 2027<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Criteria applied to 1,740 substances; 35 avoidable fish studies, about 5,000\u201310,000 animals; van Velthoven et al.\u202f(2026)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Read-across, QSAR and machine-learning models (details below)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Jadavpur University<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2023 \u2013 2026, continuing<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">15 peer-reviewed publications from the collaboration, 4 with GPC co-authors; micronucleus model submitted (2026)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Testing-avoidance methodology as Lead Registrant<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Internal<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2022 \u2013 ongoing<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Combines existing data, read-across, models and DIM criteria; study requirements reduced in about 10\u201315% of the substances assessed in 2025\u20132026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Earlier work: REACH last-resort requirement; difficult and coloured substances<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">AFSA; DTU<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2019 \u2013 2024<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Macmillan et al.\u202f(2024); DTU project 2019\u20132021<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><b><span data-contrast=\"auto\">In silico and read-across methods with Jadavpur University<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><span data-contrast=\"auto\">Together with the Drug Theoretics and Cheminformatics Laboratory at Jadavpur University (Prof.\u202fKunal Roy), GPC develops computational methods that can replace or reduce animal studies: read-across, QSAR, machine-learning models and combined approaches such as q-RASAR (quantitative read-across structure-activity relationships). GPC formulates the research questions from its experience of animal studies and of gaps in existing models, compiles training data from its own and public sources, defines the regulatory endpoints and applicability needs, and helps adapt the final models. The collaboration, running in two projects since 2023, has produced 15 peer-reviewed publications (full list in section 14), of which those below have GPC co-authors.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"8\" aria-colcount=\"4\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Endpoint (OECD test guideline)\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Approach<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Publication\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Status\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Bioconcentration in fish (TG 305)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Machine-learning q-RASAR<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Pore, <\/span><b><span data-contrast=\"auto\">Pelloux<\/span><\/b><span data-contrast=\"auto\"> et al.\u202f(2024), Journal of Hazardous Materials 479, 135725<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Published<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Fish early-life-stage toxicity (TG 210)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Intelligent consensus prediction (combined QSAR models)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Pore, <\/span><b><span data-contrast=\"auto\">Pelloux<\/span><\/b><span data-contrast=\"auto\">, <\/span><b><span data-contrast=\"auto\">Bergqvist<\/span><\/b><span data-contrast=\"auto\"> et al.\u202f(2025), Aquatic Toxicology 279, 107216<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Published<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Reproductive and developmental toxicity (TG 421\/422)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Read-across-driven classification<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Chatterjee, Pore, <\/span><b><span data-contrast=\"auto\">Szepesi<\/span><\/b><span data-contrast=\"auto\"> and Roy (2025), SAR and QSAR in Environmental Research 36(3), 247\u2013270<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Published<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Repeated-dose toxicity (TG 407, 408, 422)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Machine-learning QSAR, with experimental validation<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Pore, <\/span><b><span data-contrast=\"auto\">Szepesi<\/span><\/b><span data-contrast=\"auto\"> and Roy (2026), Chemical Research in Toxicology 39(4), 544\u2013565<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Published<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"6\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">In vivo micronucleus (TG 474)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Integrated machine learning (structural, metabolic and experimental information)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Das, <\/span><b><span data-contrast=\"auto\">Szepesi<\/span><\/b><span data-contrast=\"auto\"> and Roy, Toxicology in Vitro<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Submitted October 2026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"7\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">In vivo comet assay (TG 489)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">In silico modelling<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Das, <\/span><b><span data-contrast=\"auto\">Szepesi<\/span><\/b><span data-contrast=\"auto\"> and Roy<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">In preparation<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"8\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">NAMs in genetic toxicology<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Review of regulatory screening and NAM application<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Das, <\/span><b><span data-contrast=\"auto\">Szepesi<\/span><\/b><span data-contrast=\"auto\">, Ojha and Roy, book chapter, Comprehensive Computational Toxicology (Elsevier)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Due 30 November 2026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><span data-contrast=\"auto\">GPC authors in bold. The models cover endpoints for which animal studies are normally required under REACH, and they feed directly into the testing-avoidance methodology (below) and the chemical safety profiles (Objective 3).<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Principle.<\/span><\/b><span data-contrast=\"auto\"> As Lead Registrant for more than 200 substances, GPC could simply commission the studies ECHA requests. It chooses to research whether they can be avoided, accepting a smaller commercial gain from study management.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">6. Objective 3 \u2013 Group-based chemical safety assessment (new stream)<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><p><b><span data-contrast=\"auto\">Why it matters.<\/span><\/b><span data-contrast=\"auto\"> Assessing chemicals one by one is slow and drives repeated testing. Regulators increasingly expect grouping and read-across, but there are few well-documented reference cases showing how group assessment can be done robustly.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Research questions.<\/span><\/b><span data-contrast=\"auto\"> How can chemicals be grouped by functional group and chemistry category so that data and conclusions can be shared within a group? What evidence makes a group assessment scientifically defensible?<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Activities<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\u2022\" data-font=\"\" data-listid=\"3\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u2022&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Handbook of Chemical Safety Profiles:<\/span><\/b><span data-contrast=\"auto\"> a reference set of detailed, endpoint-by-endpoint safety profiles for about 150 chemicals, by December 2028. More than 30 profiles completed in 2025\u20132026. Each profile records the reliability of the data, the conclusion per endpoint, the remaining data gaps and any scientific basis for avoiding studies. Lead: Dr Anders Bergqvist and Dr Zsuzsanna Szepesi.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\u2022\" data-font=\"\" data-listid=\"3\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u2022&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Group assessment approaches:<\/span><\/b><span data-contrast=\"auto\"> functional-group and chemistry-category toxicological profiles developed from the Handbook, with the profiles serving as case examples for group chemical safety assessment.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ul><p><b><span data-contrast=\"auto\">Expected outcome.<\/span><\/b><span data-contrast=\"auto\"> A documented basis for group assessments that reduces the need for future studies across whole groups of substances.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><span data-ccp-props=\"{}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">7. Objective 4 \u2013 Data exchange and data mining<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><p><b><span data-contrast=\"auto\">Why it matters.<\/span><\/b><span data-contrast=\"auto\"> Relevant data often exist but are scattered across databases, literature and private data owners, so studies are repeated unnecessarily.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Activities and results<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"3\" aria-colcount=\"4\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Platform\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Period\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>What it<\/strong> <strong>does<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Results\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><b><span data-contrast=\"auto\">Datagap<\/span><\/b><span data-contrast=\"auto\"> (data mining)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">May 2026 \u2013 launch Dec 2026; internal use since Jul 2026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Searches more than 150 sources (databases, literature, data owners, handbooks, government publications), presents data by required endpoint per region, and identifies data gaps and studies needed per submission<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Platform in internal use<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><b><span data-contrast=\"auto\">Chemsortia<\/span><\/b><span data-contrast=\"auto\"> (data exchange and sale)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Mid-2024 \u2013 launch May 2027<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Centralises information on existing study data and matches it to companies\u2019 requirements; covers data GPC holds, data with other owners, and new study design where no data exist<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Data on more than 10 substances shared, avoiding 25\u201380% of new studies for those substances<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><span data-contrast=\"auto\">The platforms use the regulatory science of Objective 1 (what is required) and the methods of Objectives 2 and 3 (when existing data are enough).<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">8. Objective 5 \u2013 Cost-efficient and realistic biodegradation testing<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><p><b><span data-contrast=\"auto\">Why it matters.<\/span><\/b><span data-contrast=\"auto\"> Biodegradation kinetics experiments are expensive and slow, and standard tests use single substances at high concentrations, unlike real effluents where many chemicals degrade together at low concentrations.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><p><b><span data-contrast=\"auto\">Aims.<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><ul><li aria-setsize=\"-1\" data-leveltext=\"\u2022\" data-font=\"\" data-listid=\"4\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u2022&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><span data-contrast=\"auto\">Minimise the cost of studies on degradation kinetics by testing many chemicals together in one experiment.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\u2022\" data-font=\"\" data-listid=\"4\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u2022&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"5\" data-aria-level=\"1\"><span data-contrast=\"auto\">Simulate real situations by testing complex effluents and discharge samples.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ul><ul><li aria-setsize=\"-1\" data-leveltext=\"\u2022\" data-font=\"\" data-listid=\"4\" data-list-defn-props=\"{&quot;335551671&quot;:0,&quot;335552541&quot;:1,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\u2022&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"6\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Cut the cost and time of degradation kinetics experiments by at least 50\u201360%<\/span><\/b><span data-contrast=\"auto\"> compared with testing substances individually.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ul><p><b><span data-contrast=\"auto\">Activities and results<\/span><\/b><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"3\" aria-colcount=\"4\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Activity\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Partner\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Period<\/strong><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"256\"><p><strong>Key result\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Biodegradation kinetics of chemicals in mixtures (co-financed research)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DTU<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2019 \u2013 2022<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">GPC defined the research question (heterogeneous mixtures of industrial chemicals); Birch et al.\u202f(2023), Biodegradation and MethodsX; one paper discussed at ECHA and the EU PBT expert group<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Biodegradation of large numbers of discharged chemicals (PhD project)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DTU, IIT Bombay<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">15 Feb 2025 \u2013 Q3 2028<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">GPC proposed extending the method from GC-MS to LC-MS, so that higher-melting substances can be included; laboratory work at DTU (from Oct 2025) and in river water at IIT Bombay (from Feb 2026)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><span data-contrast=\"auto\">[Add how the 50\u201360% saving will be measured, e.g.\u202fcost and duration per substance in mixture testing versus individual testing.]<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">9. Emerging area: sustainability and ESG<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><p><span data-contrast=\"auto\">Intern projects in 2024\u20132026 analysed more than 1,000 sustainability (BRSR) reports and reviewed climate regulation and ESG reporting, enabling GPC to offer Sustainability Services. The next step is to turn the data analysis into a documented research output.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">10. Collaboration model<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"8\" aria-colcount=\"4\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Partner\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Type\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Period\u00a0<\/strong><\/p><\/td><td data-celllook=\"256\"><p><strong>Objective\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DTU<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Co-financed research; co-funded PhD<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2019\u20132022; 2025\u20132028<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">5<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">IIT Bombay<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">PhD partner<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2025\u20132028<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">5<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Jadavpur University<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Joint modelling research<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2023\u20132026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2, 3<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">AFSA Collaboration<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Industry\u2013NGO research consortium<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2023\u20132027<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"6\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Lund University \/ LTH<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Joint research, theses, internships<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2019\u20132026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">1, 4<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"7\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">KTH, RISE, industry partners<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Vinnova project<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2024\u20132025<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">1<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"8\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">S&amp;P Global<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Joint PFAS white paper<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">1<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><p><b><span data-contrast=\"auto\">Students linked to R&amp;D (2025\u20132026):<\/span><\/b><span data-contrast=\"auto\"> PFAS intern and thesis student (LTH); software and AI interns supporting the platforms.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:180,&quot;335559739&quot;:180}\">\u00a0<\/span><\/p><h2 aria-level=\"1\"><b><span data-contrast=\"none\">11. How we work<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><ol><li aria-setsize=\"-1\" data-leveltext=\"%1.\" data-font=\"\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Identify a gap<\/span><\/b><span data-contrast=\"auto\"> from practice: a test that gives no meaningful result, a missing model, a regulation that is hard to apply.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol><ol><li aria-setsize=\"-1\" data-leveltext=\"%1.\" data-font=\"\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Formulate the research question<\/span><\/b><span data-contrast=\"auto\"> and how the answer will be used.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol><ol><li aria-setsize=\"-1\" data-leveltext=\"%1.\" data-font=\"\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"3\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Choose partners<\/span><\/b><span data-contrast=\"auto\"> and agree roles, budget and publication rights in writing.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol><ol><li aria-setsize=\"-1\" data-leveltext=\"%1.\" data-font=\"\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"4\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Plan<\/span><\/b><span data-contrast=\"auto\"> with milestones, and keep project files (agreements, minutes, drafts, data).<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol><ol><li aria-setsize=\"-1\" data-leveltext=\"%1.\" data-font=\"\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"5\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Do the research<\/span><\/b><span data-contrast=\"auto\">, reviewing results continuously.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol><ol><li aria-setsize=\"-1\" data-leveltext=\"%1.\" data-font=\"\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"6\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Publish<\/span><\/b><span data-contrast=\"auto\"> in peer-reviewed journals, reports and conferences.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol><ol><li aria-setsize=\"-1\" data-leveltext=\"%1.\" data-font=\"\" data-listid=\"5\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559685&quot;:720,&quot;335559991&quot;:480,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;multilevel&quot;}\" data-aria-posinset=\"7\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Transfer results<\/span><\/b><span data-contrast=\"auto\"> into methods, platforms and services.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol><h2 aria-level=\"1\"><b><span data-contrast=\"none\">12. Timeline<\/span><\/b><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:480,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2><table data-tablestyle=\"Custom\" data-tablelook=\"0\" aria-rowcount=\"9\" aria-colcount=\"2\"><tbody><tr aria-rowindex=\"1\"><td data-celllook=\"256\"><p><strong>Year<\/strong><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"256\"><p><strong>Milestones\u00a0<\/strong><\/p><\/td><\/tr><tr aria-rowindex=\"2\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2019<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DTU mixture biodegradation project and DTU difficult-substances project start<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"3\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2022<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DTU mixture project concludes; regulatory science research and testing-avoidance methodology start<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"4\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2023<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Jadavpur collaboration on read-across and QSAR models starts; DTU mixture papers<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"5\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2024<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Intrims development and first user tests (40+ users); Chemsortia development starts; Macmillan et al.\u202f(AFSA); Vinnova biologics project<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"6\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2025<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DTU PhD starts (Feb); DIM project; Intrims patent filed (Jul); second Intrims user tests (25+ users); Global Inventory Report; Asia Chemicals Forum survey; Jadavpur papers<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"7\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2026<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DIM paper (Aug); repeated-dose toxicity paper; Datagap (May\u2013Dec); PFAS thesis and white paper; biologics manuscript; patent published (Sep); Global Chemical Regulatory Framework (Nov)<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"8\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2027<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">Intrims and Chemsortia launch; DIM next phase; PFAS method completed<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><tr aria-rowindex=\"9\"><td data-celllook=\"0\"><p><span data-contrast=\"auto\">2028<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><td data-celllook=\"0\"><p><span data-contrast=\"auto\">DTU PhD concludes; Handbook of about 150 chemical safety profiles completed<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/p><\/td><\/tr><\/tbody><\/table><h2 aria-level=\"1\">13. Managing and documenting R&amp;D\u00a0<\/h2><ol><li><b><span data-contrast=\"auto\">Monthly time recording<\/span><\/b><span data-contrast=\"auto\"> per person, by project and by R&amp;D versus other work.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><li><b><span data-contrast=\"auto\">One project register<\/span><\/b><span data-contrast=\"auto\"> with research question, objective, partners, dates, staff and status.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><li><b><span data-contrast=\"auto\">Project files<\/span><\/b><span data-contrast=\"auto\"> with agreements, plans, minutes, correspondence, drafts, data and results.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><li><b><span data-contrast=\"auto\">Development records<\/span><\/b><span data-contrast=\"auto\"> for Intrims, Datagap and Chemsortia: versions, test rounds and change logs.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><li><b><span data-contrast=\"auto\">Publication and acknowledgement policy<\/span><\/b><span data-contrast=\"auto\"> agreed with partners at the start.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><li><b><span data-contrast=\"auto\">Annual R&amp;D report<\/span><\/b><span data-contrast=\"auto\"> summarising objectives, projects, outputs and time spent.<\/span><span data-ccp-props=\"{&quot;335559738&quot;:36,&quot;335559739&quot;:36}\">\u00a0<\/span><\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>GPC Research &amp; Development Programme 2026 Objectives, research streams, collaborations and results, 2019\u20132028 Global Product Compliance (Europe) AB \u2013 internal document, October 2026 1. Purpose and overall aim\u00a0 GPC\u2019s research and development programme exists to make chemical regulation and compliance more scientific, more efficient and less dependent on new testing, especially animal testing. It turns GPC\u2019s practical experience as a regulatory partner and Lead Registrant into research questions, answers them with academic and industry partners, and builds the results into tools and services.\u00a0 The programme is organised around five research objectives:\u00a0 No.\u00a0 Objective\u00a0 Expected outcome\u00a0 1\u00a0 Regulatory science for compliance excellence and efficiency\u00a0 Systematic knowledge of how regulations are built and depend on each other, turned into real-time, portfolio-specific compliance guidance (Intrims, RegAlert)\u00a0 2\u00a0 Avoidance of unnecessary testing\u00a0 Criteria (DIM), read-across, QSAR and machine-learning models (Jadavpur University), and a methodology that show when new studies, especially animal studies, can be scientifically avoided\u00a0 3\u00a0 Group-based chemical safety assessment\u00a0 Approaches for assessing groups of chemicals, with a reference set of about 150 chemical safety profiles as case examples\u00a0 4\u00a0 Data exchange and data mining\u00a0 Platforms that find existing data, interpret it against regulatory requirements and make it available for reuse (Datagap, Chemsortia)\u00a0 5\u00a0 Cost-efficient and realistic biodegradation testing\u00a0 Methods that cut the cost and time of degradation kinetics experiments by at least 50\u201360% and simulate real, complex effluents\u00a0 The objectives build on each other: regulatory science (1) defines what data are needed; testing avoidance (2) and group assessment (3) show how needs can be met without new studies; the data platforms (4) find and share the data that already exist; and better biodegradation methods (5) make the studies that are still needed cheaper and more relevant.\u00a0 \u00a0 2. GPC R&amp;D at a glance\u00a0 Item Summary\u00a0 Base\u00a0 Ideon Science Park, Lund (Beta 5, Scheelev\u00e4gen 17)\u00a0 Core R&amp;D team\u00a0 Shisher Kumra, Dr Anders Bergqvist, Dr Zsuzsanna Szepesi,\u00a0Dr Vaibhav Diwan, Mirach Pelster\u00a0 Main partners\u00a0 DTU (Denmark), IIT Bombay, Lund University (incl.\u202fLTH), Jadavpur University, the Animal-Free Safety Assessment (AFSA) Collaboration, KTH, RISE, S&amp;P Global\u00a0 Funding\u00a0 GPC\u2019s own resources; co-financing of university projects (DTU); Vinnova-funded project with GPC in kind\u00a0 Publications\u00a0 Including four papers with Jadavpur University on read-across, QSAR and machine-learning models; peer-reviewed papers in Regulatory Toxicology and Pharmacology, Chemical Research in Toxicology, SAR and QSAR in Environmental Research and Aquatic Toxicology; further manuscripts and a book chapter in progress\u00a0 Intellectual property\u00a0 Indian patent application 202521067103 (Intrims technology), filed July 2025, published September 2026\u00a0 Products from research\u00a0 Intrims (launch 2027), RegAlert, Datagap (launch December 2026), Chemsortia (launch May 2027)\u00a0 Training\u00a0 More than 20 interns and thesis students since 2019, mainly from Lund University\u00a0 3. People and roles\u00a0 Person\u00a0 Role\u00a0 Objectives\u00a0 Shisher Kumra\u00a0 Leads the R&amp;D programme and the regulatory science research; concept and inventor of Intrims; concept for Datagap and Chemsortia\u00a0 1, 4 (and PFAS within 1)\u00a0 Dr Anders Bergqvist\u00a0 Head of toxicology (PhD Immunology, Lund University); leads the chemical safety profiles and the Handbook\u00a0 2, 3\u00a0 Dr Zsuzsanna Szepesi\u00a0 Researcher, in silico toxicology (PhD Immunology, Lund University); read-across, QSAR and machine-learning models with Jadavpur University; chemical safety profiles\u00a0 2, 3\u00a0 Dr Vaibhav Diwan\u00a0 Internship and DTU Research Manager (PhD, DTU 2019); also Business Development &amp; Growth\u00a0 1, 4, 5\u00a0 Mirach Pelster\u00a0 Researcher and developer (chemical engineer, MSc)\u00a0 1, 4\u00a0 Regulatory dossiers and other client deliverables are prepared by GPC\u2019s regulatory staff, so that R&amp;D time and client work can be kept apart.\u00a0 \u00a0 4. Objective 1 \u2013 Regulatory science for compliance excellence and efficiency\u00a0 Why it matters. Chemicals regulations worldwide differ in structure, definitions and requirements, and companies struggle to know what they must do, in which order, for each substance and market. Systematic analysis of regulations makes compliance faster, cheaper and more reliable, and helps countries design better regulation.\u00a0 Research questions. How are chemicals regulations structured, and how do their requirements depend on each other? Can best practice be identified and adapted to different countries? Can a country\u2019s chemicals inventory be predicted from its industrial structure? How can this knowledge be turned into real-time, company-specific guidance?\u00a0 Activities and results\u00a0 Activity\u00a0 Period\u00a0 Key result\u00a0 Chemicals inventory estimation model\u00a0 2022 \u2013 ongoing\u00a0 Predicts a country\u2019s inventory from its industry structure (manufacturing-, application- or consumer-intensive) and economic level; tested on three countries with 75\u201380% correct results; online tool in the Global Inventory Report (January 2025)\u00a0 Global regulatory framework and best practice\u00a0 2022 \u2013 2026\u00a0 Regulations evaluated against about 18 criteria; best practice per criterion; overall model adaptable to countries; Global Chemical Regulatory Framework (November 2026)\u00a0 Survey on the impact of chemical safety regulation\u00a0 2025\u00a0 170 industry respondents; most see a lack of regulation as harmful to business and to a level playing field (Asia Chemicals Forum 2025)\u00a0 Analysis of regulatory selection of substances for evaluation\u00a0 2024 \u2013 July 2025\u00a0 How selection for evaluation compares with substances of priority concern\u00a0 PFAS identification and regulatory implications\u00a0 2025 \u2013 March 2027\u00a0 Computational method to identify PFAS and their sub-groups and link them to legal implications; thesis, white paper with S&amp;P Global, IPI article\u00a0 Regulatory barriers to continuous manufacturing of biologics (Vinnova, Lund University)\u00a0 2024 \u2013 2025\u00a0 GPC as regulatory partner; manuscript submitted (2026); EUFEPS presentation\u00a0 From research to products\u00a0 Intrims (2024 \u2013 launch 2027): standardises the requirements of all applicable regulations into one set of compliance actions, groups them into about 20 bundles by interdependency (OR, AND, MIXED, SINGLE logics), sequences the bundles and applies them to a company\u2019s own portfolio, with automatic re-evaluation. Tested with more than 40 users (2024) and more than 25 users (2025); upgraded after testing. Patent application 202521067103 (India).\u00a0 RegAlert: real-time regulatory alerts based on the same knowledge base.\u00a0 Data foundation. Annual GPC reviews of chemicals regulations: Global Regulatory Guide, GHS Compliance guide, Global Inventory Report, Annual Summary, Compendium of Global Chemical Regulation, and the PFAS regulation overview.\u00a0 5. Objective 2 \u2013 Avoidance of unnecessary testing\u00a0 Why it matters. Many studies requested under REACH, including animal studies, are difficult, impossible or meaningless for certain substances, or could be replaced by existing data and non-animal<\/p>","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"smol_links_long_url":"","smol_links_short_url":"","smol_links_short_code":"","site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","footnotes":""},"_links":{"self":[{"href":"https:\/\/gpcregulatory.com\/fr\/wp-json\/wp\/v2\/pages\/110354"}],"collection":[{"href":"https:\/\/gpcregulatory.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/gpcregulatory.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/gpcregulatory.com\/fr\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/gpcregulatory.com\/fr\/wp-json\/wp\/v2\/comments?post=110354"}],"version-history":[{"count":0,"href":"https:\/\/gpcregulatory.com\/fr\/wp-json\/wp\/v2\/pages\/110354\/revisions"}],"wp:attachment":[{"href":"https:\/\/gpcregulatory.com\/fr\/wp-json\/wp\/v2\/media?parent=110354"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}